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Note: Some GLP-1s are not approved for weight loss, but some doctors may prescribe them off-label for this use

They may also be effective for other conditions such as fatty liver disease or osteoarthritis

By promoting weight loss and reducing inflammatory markers, tirzepatide may create conditions that allow for a gradual corticosteroid taper

Postprandial glycaemic dips predict appetite and energy intake in healthy individuals

The structures reveal a common binding pocket for negative allosteric modulators, present in both GLP-1R and GCGR 3 and located outside helices VVII near the intracellular half of the receptor