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A potential benefit of L-carnitine in these patients is based on the fact that it can (i) increase the oxidation of long-chain fatty acids which accumulation may contribute to insulin resistance in skeletal muscle, and (ii) enhance glucose utilization by reducing acyl-CoA concentration within the mitochondrial matrix (see Biological Activities) (42)

(2017) Sulfur cycling and the intestinal microbiome

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TNF- promotes Tumor Necrosis Factor Receptor 1 (TNFR1)-mediated internalization of GABA receptors, upregulates -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor expression, and enhances synaptic excitability, thereby triggering seizures and exacerbating emotional and cognitive dysfunction (Tripathi et al., 2024)

[DOI] [PubMed] [Google Scholar] 122.Serrat MA