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Have serious or unstable medical conditions without close medical supervision

However, combination therapies require careful medical supervision to monitor for interactions and optimize timing

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Research applications: oxidative stress assays, glutathione peroxidase studies, detoxification pathways, skin-lightening models

Hydrogen bonds were additionally analysed using the COOT, and the UCSF Chimera package, with relaxed distance and angle criteria (0.4 and 25-degree tolerance, respectively)