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If a patient becomes pregnant whilst taking one of these agents they should contact their doctor immediately for advice: Diarrhoea and vomiting could affect absorption of oral contraceptives which in turn may reduce effectiveness

Patients with insulin resistance or elevated baseline HbA1c often show greater appetite suppression and metabolic improvement at lower doses, while those with metabolic syndrome or fatty liver disease may require higher doses to achieve meaningful weight loss

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The GLP-1 component provides the same appetite suppression, gastric emptying delay, and glucose-dependent insulinotropic effects as in semaglutide and mazdutide

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