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These findings indicate physiologic induction of the ERM proteins in the intestinal epithelial cells of hibernating animals and support the notion that hibernation involves differential expression of gene products that may promote cellular viability at low temperatures (Lange et al., 2015)

Those who do respond often require longer treatment cycles and may achieve 70 to 90 percent improvement rather than complete resolution

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This dosage fell within the effective and safe dose range (308571 mg/kg/day) determined by the weight-tiered dosing simulations of the phase 2 trial