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Of medical importance, the discovery of the DPP-4 protease resistant exendin-4 from venom of Heloderma suspectum paved the way for the successful development of GLP-1 analogues as important treatments for insulin resistant type 2 diabetics

On the molecular level, exenatide promoted the expression of prosurvival kinase pAkt as well as antioxidant enzyme superoxide dismutase and catalase responsible for nuclear oxidative stress reduction but inhibited the expression of caspase 3 that plays a central role in cell apoptosis

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Further, T2DM remains one of the most significant risk factors not only for the development of MASLD but also for the progression of liver fibrosis and the occurrence of liverrelated complications, including HCC (Hosseinkhan et al., 2025

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