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2018;8 doi: 10.1038/s41598-018-27233-3

Most supplement companies marketing 'lipotropic pills' or oral methionine/choline products underdeliver because first-pass hepatic metabolism degrades a significant portion of orally ingested lipotropics before they reach systemic circulation

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Future studies that include people with mental health conditions will be essential, say De Giorgi and Mansur, who are both actively researching the drugs' mental health effects