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Inhibitors of DPP-4, such as sitagliptin, vildagliptin and linagliptin, inhibit DPP-4, resulting in an increase of incretin and GLP-1 secretion (Figure 1), leading to an improvement in plasma glucose control without inducing hypoglycemia or increasing the body weight.69 Both types of drugs are barely metabolized in the liver and are excreted unchanged by the kidney;70 thus, they seem to be safe in cirrhotic patients.71 Unlike the old antidiabetic drugs, their pharmacodynamic characteristics have been assessed in patients with varying degrees of hepatic impairment and their safety has been assessed in studies comprising large number of individuals

When people take tirzepatide for diabetes, the drug is called Mounjaro

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Chromatin-bound MDM2 regulates serine metabolism and redox homeostasis independently of p53