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Based on our data, we, therefore, hypothesize that TBC1D9B may regulate the function of lysosomes and lysosome-related organelles (e.g., lytic granules in T cells, melanosomes, synaptic vesicle precursors in neurons) 20,25,49 in a variety of cell physiological and pathophysiological conditions beyond nutrient starvation, as demonstrated here (Figs

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Treatment with oral semaglutide improves the fasting lipid level profile, as exploratory analysis resulted in a statistically superior reduction in total cholesterol [35, 38, 42], low-density lipoprotein (LDL) [35, 42], triacylglycerols (TAGs) [35, 38, 39], and very-low-density lipoprotein (VLDL) compared to the effects of placebo [38]

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