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Metformin frequently causes gastrointestinal side effects including diarrhea, nausea, abdominal discomfort, and metallic taste, affecting approximately 20-30% of patients, particularly during initiation

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Archived from the original on May 12, 2021

Andretto V, Rosso A, Zilio S et al (2024) Peptide-based hydrogel for nanosystems encapsulation: the next generation of localized delivery systems for the treatment of intestinal inflammations

Understanding these factors helps explain why some peptides work best via injection, while others require molecular modifications or specialized carriers for oral use