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Ingelfinger, MD, from @tuftsmedschool and the Maine Medical Center Institute for Research: nejm.org/doi/full/10.10 GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure

The specific effects of GLP-1R agonism on food avoidance, food aversion and emetic behaviors have been delineated more clearly in recent years

It helps regulate metabolism by influencing how the body uses carbohydrates, fats, and proteins for energy

In the adult brain, glial cells and neurons continue to express the GATM and GAMT genes, however, populations of cells express only the GATM gene while others express only the GAMT gene

The mechanism of action of paracetamol is beyond the scope of this discussion