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A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) (Sorokin et al., 1986)

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doi: 10.1007/s00125-010-1896-4

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In addition, surface transporters of epithelial cells, such as glucose transporter GLUT2 and amino acid transporter SGLT1, can specifically transport nutrients, further enhancing the selectivity of permeability