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Small substituents at the 4-position (e.g., chloro, fluoro, cyano) provided the greatest potency

In our experiments, exogenous rapamycin significantly decreased the proportion of SA--Gal-positive cells and p16 expression, whereas autophagy inhibitors 3-MA and Baf-A1 produced opposite effects

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Given the effects of GLP-1 receptor agonists on body weight and fat, the question arises of whether a reduction in kidney-specific fat depots could contribute to the kidney-protective effects of GLP-1 receptor agonist treatment

There were significant changes in the liver transcriptome in response to semaglutide, as shown by separated clustering of the two groups of samples (Figure 4A)