Gastrointestinal effects are experienced by a significant proportion of patients, particularly during dose initiation and escalation: Nausea (affecting up to 20% of patients) is typically most pronounced in the first few weeks and often diminishes with continued use [10] [11] Diarrhoea or constipation may occur as the digestive system adjusts to slower gastric emptying Abdominal discomfort, bloating, or indigestion are common but usually mild Vomiting occurs less frequently but may necessitate dose adjustment These gastrointestinal symptoms can be minimised by eating smaller, more frequent meals, avoiding high-fat foods, and ensuring adequate hydration
We note that a patient's lack of understanding of clinical care instructions provided after a procedure and other aspects of health literacy have been linked to poor adherence to treatment, decreased patient safety, increased return to the emergency department, and lower levels of patient satisfaction
8 Select Common Causes of Drug-Induced Seizures It is not difficult to imagine seniors at risk for drug-induced seizures when an offending agent is used in circumstances that may increase their risk, including comorbidities, polypharmacy, medication-adherence problems, errors in administration (i.e., due to vision difficulties, misunderstanding, dementia), and age-related reduced medication clearance (e.g., renal and hepatic impairment)
Regulatory authorities require extensive long-term safety data before licensing decisions are made
Another aspect is the presence of heavy metals
