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Effect of Combination Therapy on Metabolic Outcomes Based on a 2019 meta-analysis of seven randomised controlled trials (1,913 participants) with a primary duration ranging from 12 to 30 weeks, co-administration of SGLT-2 inhibitors and GLP-1 receptor agonists had a less than additive effect on HbA 1c and body weight and an additive reduction in systolic blood pressure compared with each monocomponent without increasing risk of hypoglycaemia [5]

doi:10.1016/s0140-6736(21)00213-0 11.Wadden TA, Bailey TS, Billings LK, et al

After a couple of weeks I really started noticing the appetite control

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Semaglutide slows gastric emptying while your gallbladder works harder to process fat, creating digestive conflict