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Indeed, Arabidopsis rax1 mutants carrying a mutation in the GSH1 enzyme leading to only 2050% of wild-type GSH are affected in stress signaling and have induced defense pathways (Ball et al., pad2 , is not capable of activating appropriate defense mechanisms against biotic stressors (Parisy et al., rml1 , which contains only 210% of wild-type glutathione (Vernoux et al., rml1 mutant seedlings show impaired root development, which is assumed to be caused by redox-dependent inhibition of cell cycle components (Vernoux et al., Better understanding of redox-regulatory processes mediated by glutathione demands experimental approaches enabling quantitative monitoring of E GSH

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It is administered as a once-daily subcutaneous injection