efficacy of semaglutide Levels circulating determine reductions in HbA1c and body weight in people with type 2 diabetes: Cell Reports Medicine Semaglutide vs. Tirzepatide for Obesity

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doi: 10.1255/ejms.965

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"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity