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In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012

The injection works systemically, controlling hunger signals in your brain regardless of whether you eat immediately before or after your weekly dose

Still, there is no universal day when side effects begin or a guarantee that they disappear by month 3

Shirani MP, Ensafi AA, Rezaei B, Amirghofran Z

Preserved incretin activity of glucagon-like peptide 1 7-36 amide but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus