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(GSM is strongly linked to low oestrogen.) Infection risk : diabetes control, recent antibiotics, SGLT2 inhibitors, immunosuppression, sexual exposures
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However, which signaling pathway produces the unwanted side effects (such as respiratory suppression and constipation) is currently controversial: one view is that it is caused by -arrestin signal transduction, and the other view suggests that the respiratory depression by opioids is caused due to G protein-gated inwardly rectifying potassium (GIRK) channel signaling