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Safety Note: If you notice a new lump or swelling in your neck, experience persistent hoarseness, difficulty swallowing, or shortness of breath, you must seek urgent medical attention from your GP or A&E

In hEDS-associated neuropathic POTS where partial sympathetic denervation of the lower extremity vasculature produces blunted vasoconstriction, blood already pools in peripheral capacitance vessels on standing, stroke volume is structurally reduced, and the sympathetic nervous system is already operating near its compensation ceiling the additional vasodilatory and chronotropic load imposed by chronic dual incretin receptor agonism may have limited physiological reserve to absorb it

A 24-hour clear liquid diet can be used as a risk-reduction strategy, but it can not be considered a substitute for clinical judgment or a guarantee against aspiration risk

UNS Glutathione NAC is a dietary supplement in capsule form, containing N-acetylcysteine (NAC) and glutathione

Hermann W, Schorr H, Obeid R, Geisel J