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As mentioned previously, the A1 astrocyte phenotype, induced by microgliaderived IL1, TNF, and C1q, loses its neuroprotective functions and secretes neurotoxic and proinflammatory mediators that exacerbate neuronal damage

SS-31 addresses the cellular mechanism underlying this pattern Longevity & Healthy Aging Mitochondrial decline is considered one of the nine hallmarks of cellular aging identified in the landmark 2013 paper by Lopez-Otin et al