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The cardiovascular indication rests on SUSTAIN 6, a multi-center, placebo-controlled, double-blind outcomes trial in which 3,297 patients with inadequately controlled type 2 diabetes and atherosclerotic cardiovascular disease were randomized to Ozempic 0.5 mg or 1 mg weekly or placebo for a minimum observation time of two years

Injectable glucon-like peptide-1 (GLP-1) medications have skyrocketed in popularity due to their clinically significant effects on weight loss and the management of certain health conditions

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Based on these results, in the current study, we also investigated the effect of GLP-1RA on secretion of selected adipokines (irisin, visfatin/NAMPT and adiponectin) related to the sirtuin pathway