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With enormous diversity in chemical and physiological properties, these molecules serve a wide variety of purposes, including as important components of the bacterial cell envelope 7,30,34 , providing protection against desiccation and toxic substances 87,88,89 , mediating attachment to surfaces 87,90 , biofilm formation 91,92 , host interaction 93,94 , and bacterial motility 58,60

Taken together, we identified CD38 as a potential immunometabolic checkpoint in CD4 + T cells from pre-symptomatic APP carriers that could be targeted in AD

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R., & Brown, L