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Retatrutide is increased slowly in clinical trials to help the body adjust to the medicine and reduce the risk of side effects

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doi: 10.1016/j.neuropharm.2017.08.022 81 HuangJLiuYChengLLiJZhangTZhaoGet al

The addition of cagrilintide (which also slows gastric emptying through amylin receptor-mediated pathways) may contribute to some additive GI effects, particularly during the initial dose titration

Healthcare providers often recommend continuing the program until clients achieve their target weight and establish healthier eating and activity patterns