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The HPLC system used a hydrophilic interaction chromatography (HILIC) analytical column (Ascentis Express 2.1 mm 150 mm, 2.7m)

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95% CI, 0.64-0.88

With the evolving evidence and guidelines across the world, we should now choose second-line agents such as SGLT2i and GLP1-RAs with proven CV benefits in patients with high CV risk followed by agents with proven CV safety if additional glycemic control is required