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Whilst vitamin B12 toxicity is exceptionally rare, very high levels from supplements or injections have been associated with skin reactions such as acne-like eruptions

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The great importance of the former lies in that it has permitted us to see the origin of the bulk properties of the protein, which result from averaging over the whole population, However, when it comes to the conversion of one structure into another, and to render account of any dynamic function of the protein, consideration of the stochastic species is indispensable (Weber, 1975)