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In some cases, like acetaminophen overdose, the mechanism is well established

Introduction L-carnitine is a ubiquitously occurring trimethylated amino acid that plays an important role in the transport of long chain fatty acids across the inner mitochondrial membrane [1]

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Similarly, 'Ozempic foot', in which the bones of the foot become more prominent and pain develops, has been interpreted as pain caused by reduced fat diminishing the cushioning function of the heel and ball of the foot