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Large-scale clinical trials with semaglutide (STEP 1) found that roughly 40% of total weight loss came from lean body mass (LBM), which is higher than the roughly 25% expected during typical physiological weight loss (the so-called "quarter fat-free mass rule")

In addition to promoting efficient metabolism, it also helps with lean muscle support and weight management

These indicators are divided into positive, e.g., delusions, cognitive disruptions, and hallucinations, and negative symptoms, e.g., difficulties in social interaction, lack of motivation, reduced natural speech, and an inability to experience pleasure