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ACE2, a peptidase that exists on the cell surfaces of most organs (Hamming et al., 2004), is one of the most crucial key players in induction of redox stress (Shatizadeh Malekshahi et al., 2022)

Taken together, the widespread expression of VDRs and vitamin Dmetabolizing enzymes throughout the aging brain supports the plausibility of vitamin D as a neuromodulator in later life

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