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In animal models, even short bouts of voluntary wheel running, ranging from a few hours to several days, can rapidly elevate BDNF expression in the hippocampus

An extended-release formulation of exenatide was subsequently developed for once-weekly administration by incorporating exenatide into an extended-release microsphere formulation [19]

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Hypoxia also activates the hypothalamo-pituitary-adrenal (HPA) axis, raising plasma levels of adrenocorticotropic hormone and cortisol, another mechanism that regulates IGFBP expression[197]

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