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Electrolytes remain important during the transition, particularly if you are maintaining a high-protein, moderate-calorie diet

Your genetic makeup influences how efficiently your cells bind to these receptors, directly affecting medication tolerance and side effect severity

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This is especially important if you have kidney problems

In a statement to WIRED, a Lilly spokesperson Niki Biro noted that, given its effectiveness, retatrutide is currently being targeted to those with high BMI or with obesity-related complications that require a high degree of weight loss, where the clinical need may be greater. Biro also cautions that retatrutide is an investigational molecule that is legally available only to participants in Lillys clinical trials