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Community-derived FOXO4-DRI daily dosing ladder Week Weeks 1-4 Daily Dose 250 mcg Week Weeks 5-8 Daily Dose 375 mcg Week Weeks 9-12 Daily Dose 500 mcg Week Weeks 13-16 Daily Dose 500 mcg Reported community dosing only

Progress often stalls because the underlying drivers have not been adequately resolved

A foul or unusual smell could indicate microbial contamination

Its Phase 3a REDEFINE 1 and REDEFINE 2 trials are published and complete, but the product remains investigational while its benefitrisk profile is evaluated