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Product quality variability in purity, oxidation, and labeling across supplements is a serious concern

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If combined with insulin or medications that increase insulin in the body, there may be a possibility of hypoglycemia (low blood sugar)

For instance, reduced mtDNA copy number in subcutaneous adipose tissue is a well-documented feature of the lipoatrophy caused by older NRTIs like stavudine (d4T) and zidovudine (AZT), as mtDNA depletion impairs adipocyte differentiation and triglyceride storage

A prospective, randomized, 3-month, controlled, assessor-blinded study