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1 Introduction 1.1 Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords Parkinsons disease, -synuclein, dopaminergic neurons, LRRK2, mitochondrial dysfunction, comorbidities, levodopa, and neuroinflammation. Studies published in English between 2000 and 2025 were included

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In addition, dendritic cells in the tumor microenvironment can secret IGF and support T-ALL growth by activating IGF-IR [189]

lactate, and reactive oxygen species Reactive oxygen species Molecules or ions formed by the incomplete one-electron reduction of oxygen