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Fatigue on GLP-1 medications is typically caloric-restriction-related, not oxidative-stress-related

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Human trials of GLP-1 medications in women with PCOS have found (2): Ovulation rates of 86% in women taking GLP-1s alongside metformin - compared to 29% on metformin alone, a threefold improvement 62% of women on GLP-1s had more regular menstrual cycles, versus 28% on placebo Significant reductions in testosterone levels These are meaningful numbers for a condition where restoring ovulation and cycle regularity remains one of the challenges

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Also consult a clinician if you suspect a genetic cause or have a history of liver disease