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4749 Given that the epistatic interactions presented here are key to folate-related thymidylate and methylation pathways, it seems likely that environmental factors such as UVR will prove to be an important determinant of disease occurrence in future studies

Patients may be seen in Hollywood, FL, or by telehealth when appropriate

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Proportions of responders were 50.1% and 45.4% at week 12, 51.2% and 48.7% at week 24, and 43.7% and 44.5% at week 48 in the glycopyrrolate/eFlow CS and tiotropium groups, respectively

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