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2) Glycaemic control endpoints in type 2 diabetes research protocols Retatrutide has also been evaluated in a phase 2 type 2 diabetes trial (The Lancet) that measured: HbA1c change at 24 weeks body weight change at 24 weeks adverse events and discontinuations within the protocol The paper reports dose dependent improvements in both glycaemic and weight outcomes in the trial setting, which is why retatrutide is often discussed as a next generation metabolic peptide for integrated glycaemic and weight endpoints in published clinical research