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Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage

External resources PubMed - National Library of Medicine (search "probiotics GLP-1" or "semaglutide microbiome" for primary research) National Institute of Diabetes and Digestive and Kidney Diseases - Digestive Diseases International Scientific Association for Probiotics and Prebiotics (ISAPP) World Gastroenterology Organisation - Probiotics and Prebiotics Navigating semaglutide side effects does not have to be a guessing game