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Indole Indirectly Stimulates Colonic Submucosal Neurons Through the Activation of GLP-1 Receptors (GLP-1Rs) Indole can penetrate the gut barrier (Jaglin et al., 2+ ] i ) in underlying submucosal neurons, important neural regulators of GI absorpto-secretory function, was unchanged in its presence (1 mM, n = 32 neurons from three SMP preparations, Figure 3A)