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This ceramide deficiency means that acid molecules penetrate deeper and faster than they would in intact skin, reaching the viable epidermis at concentrations that are irritating or damaging rather than therapeutic

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Different types of CRF and different CRF receptors have been identified not only in CNS but also in the enteric nervous system

The current data do not establish direct causal links, and further studies employing pathway-specific inhibition or genetic approaches will be required to clarify the precise molecular mechanisms involved