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GPX4 catalyzes the reduction of phospholipid hydroperoxides (PLOOHs) using GSH as a cofactor, thereby generating oxidized glutathione (GSSG) and non-toxic phospholipid alcohols (PLOHs)

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Beyond that landmark study, the evidence base includes research showing GHK-Cu enlarges hair follicle size, extends the anagen (active growth) phase, stimulates dermal papilla cells (the cells that control follicle activity), promotes angiogenesis (blood vessel growth) to the scalp, and reduces the DHT-related inflammation that causes follicle miniaturization in androgenetic alopecia

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For instance, young individuals have measurably higher circulating MOTS-c compared to middle-aged and elderly individuals