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However, in contrast to simple obesity, where GH is low and IGF-I within normal range (89), subjects with MASLD demonstrate variable changes in the GH/IGF-I axis depending on disease severity (121123) ( Table 1 )

36,37 As a result of the activation of stellate cells and a subsequent enhancement in collagen and extracellular matrix synthesis, the space of Disse becomes thickened, so that capillarization develops and the normal fenestrated architecture of the sinusoidal endothelium is lost

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Mitochondria and other metals Mitochondria and copper metabolism As an essential trace element, copper is obtained mainly through the digestion of food, followed by absorption in the intestines, and transport into cells by DMT1 and transmembrane copper transporter 1 (Fig