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It wasnt until September 2023 that the FDA required a warning for ileus and intestinal blockage for these drugs

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394 P2Y6R, which also belongs to the purinergic receptor family, is involved in inflammatory responses and immune regulation by regulating the signaling of extracellular nucleotides (e.g., UDPs) and effectively ameliorates the effects of DSS-induced ulcerative colitis in mice