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Moreover, it is implicated in the pathophysiology of metabolic, cardiovascular, and malignant diseases [149]

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In addition, atypical antipsychotics have been shown to increase orexigenic neuropeptide Y (NPY) expression and activate the cellular energy sensor AMP-activated protein kinase (AMPK) in the hypothalamus, effects that are dependent on functional H1Rs (171, 179)

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