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Oral corticosteroids (prednisone) provide short-term anti-inflammatory benefit but have significant side effect profiles with repeated courses, including bone density loss, immune suppression, and metabolic disruption

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

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Several herbs, spices, vitamins, foods, vegetables, etc., are reported to be sources of exogenous antioxidants

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