Currently, there are several therapies emerging and undergoing trials in animal models that focus on the manipulation and administration of several growth factors implicated in the healing process (Halper 2014
G.HolzbaurE
To support rapid proliferation, cancer cells take up more glucose for glycolysis even in the presence of oxygen, a phenomenon known as the Warburg effect 2
Although radiation therapy is effective in prolonging patient survival, local recurrences may actually be promoted by radiation therapy through activation of EGFR, IGF-1R, and PDGFR [107, 108], while inhibition of these pathways increases radiosensitivity [108]
Many other molecules that participate in autophagy routing are selective receptors (SAR) for cargos to be degraded by lysosomal enzymes (Venediktov et al., 2023), although HSP70s may also engage additional machinery