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Future work will therefore focus on combining XChem hit matter with the main NMR hit series through structure-guided merging and linking of fragments to design more potent, drug-like, and cell-permeable tool compounds

Marshall sees both adults and adolescents with functional GI issues and modifies her approach based on age, lifestyle, and tolerance

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While this interaction is not expected to be clinically significant for most drugs, caution is advised when Tirzepatide is co-administered with oral medications that have a narrow therapeutic index (e.g., warfarin), where small changes in exposure could have significant clinical consequences

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