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His work has led to advances in the understanding of how cells dispose of misfolded proteins that cause cellular dysfunction as well as the development of a pipeline of ATD drugs that could eliminate the need for liver transplantation in those with the disorder

In HF, when mitochondrial oxidative metabolism and ATP synthesis decrease, it is frequently offset by an augmented glycolytic response (61)

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Unusual examples have been reported in the muscles of the head and neck, the forearm, scrotum, and small muscles of the hand