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Plus, there are a number of, so far, unclear mechanisms of action that may have effects on other systems in the brain and body. He says, for example, GLP-1 drugs seem to down-regulate dopamine responses in the brain

"While some plant compounds may indirectly influence GLP-1 pathways or mimic some GLP-1 effects, they are not equivalent to pharmaceutical GLP-1 receptor agonists," says Kumar