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In addition to intracellular effects, itaconate is secreted from activated macrophages, particularly within the tumor microenvironment, where it exerts numerous additional effects

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This suggests that MORs on PVN Glu neurons may influence colonic water absorption, but not appear to directly regulate colonic motility

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[DOI] [PubMed] [Google Scholar] 145.Wang X, Desai K, Chang T, Wu L

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